Valerian (Valeriana officinalis)


The efficacy and tolerance of a valerian tablet (Valeriana officinalis) was evaluated against placebo in the treatment of insomnia (E.U. Vorbach and K.H. Arnold). This randomized, double-blind study was conducted on 121 patients with diagnosed insomnia not due to organic causes. Patients were studied over four weeks and the daily dosage of valerian extract was 600 mg (equivalent to about 2400 mg of dried root and rhizome) taken in the evening.

Valerian: Binding of Brain Receptor Sites Studied

Reference: Mennini T, Bernasconi P: In vitro study on the interaction of extracts and pure compounds from Valeriana officinalis roots with GABA, benzodiazepine and barbiturate receptors. Fitoterapia 64: 291-300, 1993

Phytotherapy Review & Commentary: Valerian; Clinical Overview

A major challenge facing healthcare practitioners today is safe and non-addictive medications for anxiety and insomnia. This category has largely been dominated in the last two decades by benzodiazepines like diazepam and alprazolam. While these drugs have been very useful in the management of more severe cases of anxiety, potential addiction and serious side effects secondary to withdrawal have cast a shadow over their long-term efficacy.

Study on Valerian/Hops Combination Sheds Light on Mechanism of Action in Promoting Sleep

This article focuses on the research paper "The Fixed Combination of Valerian and Hops (Ze91019) Acts Via a Central Adenosine Mechanism," by R. Schellenberg, S. Sauer, E.A. Abourashed, U. Koetter...


Describes the sedative effect identified in a lignan compound of a valeriana officinalis. Assumption that valerian intervenes with a brain neurotransmitter which produces tiredness; Mechanism of ...

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