Methionine

Optimal Methionine-Free Diet Duration for Nitrourea Treatment

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In animal models, methionine (MET) restriction in association with chloroethylnitrosoureas led to a substantial improvement. On this basis, we initiated a Phase I clinical trial of dietary MET re...

Dietary Supplement S-Adenosyl--Methionine (AdoMet) Effects on Plasma Homocysteine Levels in Healthy Human Subjects

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Dietary Supplement S-Adenosyl--Methionine (AdoMet) Effects on Plasma Homocysteine Levels in Healthy Human Subjects: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

Objectives: To determine if exogenous S-adenosyl--methionine (AdoMet), a commonly used nutritional supplement, increases the level of plasma homocysteine (Hcy), a potential cardiovascular risk fa...

Nutrient Intake and Nutritional Indexes in Adults With Metastatic Cancer on a Phase I Clinical Trial

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Nutrient Intake and Nutritional Indexes in Adults With Metastatic Cancer on a Phase I Clinical Trial of Dietary Methionine Restriction

Animal studies have shown that dietary methionine restriction selectively inhibits growth of a variety of human tumor xenografts but has relatively few deleterious effects on normal tissues. The ...

Molecular Mechanisms of Cell Cycle Block by Methionine Restriction in Human Prostate Cancer Cells

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Previous studies have shown that dietary or pharmacological methionine restriction inhibits growth of human prostate cancer cells in vitro or as xenografts in mice. We undertook the present studi...

Methionine Restriction Inhibits Colon Carcinogenesis

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Abstract: Previously, we demonstrated that life-long methionine restriction (MR) in rats increases life span and inhibits aging-related disease processes. The present study examines the effects o...

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