Sulforaphane (e.g. Broccoli Sprouts)

Sulforaphane (e.g. Broccoli Sprouts)

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BROCCOLI: Providhig Cancer Protection, Liver Support, and Essential Nutrients

One important way to protect
yourself from the lethal scourge
of cancer that is destroying the
lives of millions of Americans is
to regularly consume cruciferous
vegetables such as broccoli, cau-
liflower, cabbage, and Brussels
sprouts. This particular group of
vegetables is an excellent source
of unique cancer-figbting chemi-
cals knowi^ as glucosinolates. Once
inside the body, glucosinolates are
transformed into powerful metab-
olites such as indole-3-carbinoI
(I3C) and isothiocyanates (includ-
ing sulforaphane). These phyto-
chemical compounds have been
shown to protect against a broad
range of potentially lethal threats,
including colon, breast, pros-
tate, thyroid, cervical, and other

Attacking Cancer
The remarkable compounds
derived from broccoli work through
numerous mechanisms to inhibit
cancer cells. Some produce ben-
eficial changes in gene expression,
thus altering levels of key proteins

and enzymes, while others inhibit
tumor cell adhesion, spread, and
invasion. Most recently, scientists
have shown that a particular crucif-
erous vegetable compound known
as phenethyl isothiocyanate (PEITC)
directly inhibits a tumor's ability
to supply itself with blood.^ This
interruption of angiogenesis is
considered an important cancer-
fighting mechanism.
Another broccoli compound
known as sulforaphane induces
cancer cells to commit cellular
suicide, whiie other compounds—
particularly i3C, or its conden-
sation product, 3,3'-diindolyl-
methane (DIM)—interrupt the
ability of cancer cells to repro-
duce.'-^-''^'^'" "I3C and DIM affected
the expression of a large number
of genes that are related to the
control of carcinogenesis, cell
survival, and physiologic behaviors,"
noted one research team." Recent
studies suggest that at high con-
centrations, these compounds may
interact with one another to thwart
cancer in a synergistic manner.
In order to achieve a high enough
concentration of these effective
cancer-fighting compounds, it
may be necessary to also use
Scientists in California dem-
onstrated that I3C interferes with