N-acetylcysteine (NAC) inhibits LDL oxidation


We investigated the ability of NAC to inhibit LDL oxidation. NAC inhibited in vitro LDL oxidation induced by copper sulfate, 2,2'-azobis(2-amidinopropane) dihydrochloride, and UV light, and protected LDL against depletion of antioxidant vitamins. Glutathione was similarly effective against copper-mediated LDL oxidation. Sequential additions of NAC slowed down LDL oxidation more effectively than the initial addition of the same total dose. NAC reduced antibody formation during the oxidation of native LDL by oxidized LDL. NAC's effectiveness as an inhibitor of LDL oxidation is dependent on the timing sequence of the oxidation reaction, sequential additions of NAC, and the presence of previously oxidized LDL.

Atherosclerosis, 1998, Vol 138, Iss 2, pp 319-327

Life Extension Foundation.

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