Eugenol and Curcumin are Hepatoprotective Against Iron Overload


Eugenol and Curcumin are Hepatoprotective Against Iron Overload

Reference: Reddy AC, Lokesh BR. Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats. Toxicology 1996; 107:39-45.

Summary: The effects of eugenol and curcumin on iron-induced liver damage were evaluated in 36 male rats by measuring liver lipid peroxidation and serum levels of hepatic enzymes (SGPT, SGOT, LDH). The animals were divided into three treatment groups. One received curcumin (30 mg/kg body weight in 1 ml of ground nut oil (GNO)); a second received eugenol (100 mg/kg body weight in 1 ml of GNO); and the control received GNO alone (1 ml) for 10 days. At the end of the ten-day period, half of the rats in each of the three groups were injected with 30 mg iron in saline/kg body weight, while the other half received only saline. The results showed that oral administration of curcumin lowered the lipid peroxide levels by 27% in the saline-injected group and by 24% in the iron-injected group. Eugenol had similar results, lowering lipid peroxide levels by 20% and 38% in the saline- and iron-injected groups respectively. In the iron-treated animals, the oral administration of curcumin or eugenol was found to reduce the SGPT levels by 27% and 26%, SGOT by 32% and 31% and LDH by 28% and 23% respectively as compared to controls.

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