Aspects of Mild Thiamine Deficiency

Aspects of Mild Thiamine Deficiency

Reference: Wilkinson TJ, Hanger HC, Elmslie J, et al. The response to treatment of subclinical thiamine deficiency in the elderly. Am J Clin Nutr 1997; 66:925-8.

Summary: The erythrocyte thiamine levels were measured twice in 222 people over 64 years old in New Zealand. Three months passed between the two measurements. A total of 96 were found to have low levels at one or both measurements, and 76 of these were randomized to receive 10 mg thiamine or placebo daily for three months. Daily alcohol intake was significantly higher among those who had low erythrocyte thiamine levels at both measurements compared to those low at only one measure. The level of alcohol ingested was not excessive for anyone, however. Thiamine supplementation in those with consistently low erythrocyte thiamine levels (but not those with only one reduced value) improved erythrocyte thiamine levels and also quality of life, systolic blood pressure and weight compared to placebo. There was a trend toward improvement in energy and sleep as well in those taking thiamine. Measures of cognitive function and neuropathy symptoms were not affected by thiamine.

Natural Product Research Consultants, Inc.
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By E. Yarnell

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