Circulatory System


The Circulatory System

The bodily system consisting of the heart, blood vessels, and blood that circulates blood throughout the body, delivers nutrients and other essential materials to cells, and removes waste products. Also called cardiovascular system.

A group of organs that transport blood and the substances it carries to and from all parts of the body. The circulatory system can be considered as composed of two parts: the systemic circulation, which serves the body as a whole except for the lungs, and the pulmonary circulation, which carries the blood to and from the lungs. The organs of circulatory system consist of vessels that carry the blood and a muscular pump, the heart, that drives the blood.

Of the vessels, the arteries carry blood away from the heart; the main arterial vessel, the aorta, branches into smaller arteries, which in turn branch repeatedly into still smaller vessels and reach all parts of the body. Within the body tissues, the vessels are microscopic capillaries through which gas and nutrient exchange occurs (see respiration). Blood leaving the tissue capillaries enters converging vessels, the veins, to return to the heart and lungs. The human heart is a four-chambered organ with a dividing wall, or septum, that separates it into a right heart for pumping blood from the returning veins into the lungs and a left heart for pumping blood from the lungs to the body via the aorta.

An auxiliary system, the lymphatic system, is composed of vessels that collect lymph from body tissues. Carried to converging vessels of increasing size, the lymph enters the thoracic duct and is emptied into a large vein near the heart.

Systemic Circulation

In the systemic circulation, which serves the body except for the lungs, oxygenated blood from the lungs returns to the heart from two pairs of pulmonary veins, a pair from each lung. It enters the left atrium, which contracts when filled, sending blood into the left ventricle (a large percentage of blood also enters the ventricle passively, without atrial contraction). The bicuspid, or mitral, valve controls blood flow into the ventricle. Contraction of the powerful ventricle forces the blood under great pressure into the aortic arch and on into the aorta. The coronary arteries stem from the aortic root and nourish the heart muscle itself. Three major arteries originate from the aortic arch, supplying blood to the head, neck, and arms. The other major arteries originating from the aorta are the renal arteries, which supply the kidneys; the celiac axis and superior and inferior mesenteric arteries, which supply the intestines, spleen, and liver; and the iliac arteries, which branch out to the lower trunk and become the femoral and popliteal arteries of the thighs and legs, respectively. The arterial walls are partially composed of fibromuscular tissue, which help to regulate blood pressure and flow. In addition, a system of shunts allows blood to bypass the capillary beds and helps to regulate body temperature.

At the far end of the network, the capillaries converge to form venules, which in turn form veins. The inferior vena cava returns blood to the heart from the legs and trunk; it is supplied by the iliac veins from the legs, the hepatic veins from the liver, and the renal veins from the kidneys. The subclavian veins, draining the arms, and the jugular veins, draining the head and neck, join to form the superior vena cava. The two vena cavae, together with the coronary veins, return blood low in oxygen and high in carbon dioxide to the right atrium of the heart.

Pulmonary Circulation

The pulmonary circulation carries the blood to and from the lungs. In the heart, the blood flows from the right atrium into the right ventricle; the tricuspid valve prevents backflow from ventricles to atria. The right ventricle contracts to force blood into the lungs through the pulmonary arteries. In the lungs oxygen is picked up and carbon dioxide eliminated, and the oxygenated blood returns to the heart via the pulmonary veins, thus completing the circuit. In pulmonary circulation, the arteries carry oxygen-poor blood, and the veins bear oxygen-rich blood.

The Body's Filtering System

The organs most intimately related to the substances carried by the blood are the kidneys, which filter out nitrogenous wastes and regulate concentration of salts; the spleen, which removes worn red blood cells, or lymphocytes; and the liver, which contributes clotting factors to the blood, helps to control blood sugar levels, also removes old red blood cells and, receiving all the veins from the intestines and stomach, detoxifies the blood before it returns to the vena cava (see urinary system).

Circulatory Disorders

Disorders of the circulatory system generally result in diminished flow of blood and diminished oxygen exchange to the tissues. Blood supply is also impeded in such conditions as arteriosclerosis and high blood pressure (see hypertension); low blood pressure resulting from injury (shock) is manifested by inadequate blood flow. Acute impairment of blood flow to the heart muscle itself with resulting damage to the heart, known as a heart attack or myocardial infarction, or to the brain (stroke) are most dangerous. Structural defects of the heart affecting blood distribution may be congenital or caused by many diseases, e.g., rheumatic fever, coronary artery disease.

Part II, The Circulatory System

The system in the body by which blood and lymph are circulated. The parts of the circulatory system include the heart, along with all the arteries, veins, and capillaries. The organs of the lymphatic system are also considered to be part of the circulatory system. Nutrients, oxygen, and other vital substances are carried throughout the body by the blood, which is pumped by rhythmic contractions of the heart. Blood is pumped from the heart to the arteries, which branch into smaller and smaller vessels as they move away from the heart. The blood passes oxygen and nutrients to the cells and picks up waste in the capillaries, then returns to the heart via a system of veins.

Wikipedia: circulatory system

The circulatory system (or cardiovascular system) is an organ system that moves nutrients, gases, and wastes to and from cells, and helps stabilize body temperature and pH to maintain homeostasis. While humans, as well as other vertebrates have a closed circulatory system, some invertebrate groups have open circulatory system. The most primitive animal phyla lack circulatory systems.

Human circulatory system

The main components of the human circulatory system are the heart, the blood, and the blood vessels.
Furthermore, these components can either belong to the systemic circulation and the pulmonary circulation. The systemic circulation is the main part of the circulatory system, while the pulmonary system oxygenates the blood.

Systemic circulation

Systemic circulation is the portion of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart.

In the systemic circulation, arteries bring oxygenated blood to the tissues. As blood circulates through the body, oxygen diffuses from the blood into cells surrounding the capillaries, and carbon dioxide diffuses into the blood from the capillary cells. Veins bring deoxygenated blood back to the heart.

The release of oxygen from red blood cells or erythrocytes is regulated in mammals. It increases with an increase of carbon dioxide in tissues, an increase in temperature, or a decrease in pH. Such characteristics are exhibited by tissues undergoing high metabolism, as they require increased levels of oxygen.

Pulmonary circulation

Pulmonary circulation is the portion of the cardiovascular system which carries oxygen-depleted blood away from the heart, to the lungs, and returns oxygenated blood back to the heart. De-oxygenated blood enters the right atrium of the heart and flows into the right ventricle where it is pumped through the pulmonary arteries to the lungs. Pulmonary veins return the now oxygen-rich blood to the heart, where it enters the left atrium before flowing into the left ventricle. From the left ventricle the oxygen-rich blood is pumped out via the aorta, and on to the rest of the body.


In the heart there is one atrium and one ventricle for each circulation, and with both a systemic and a pulmonary circulation there are four chambers in total: left atrium, left ventricle, right atrium and right ventricle.

Closed circulatory system

The circulatory systems of humans is closed, meaning that the blood never leaves the system of blood vessels. In contrast, oxygen and nutrients diffuse across the blood vessel layers and enters interstitial fluid, which carries oxygen and nutrients to the target cells, and carbon dioxide and wastes in the opposite direction.

Other vertebrates

The circulatory systems of all vertebrates, as well as of annelids (for example, earthworms) and cephalopods (squid and octopus) are closed, just as in humans. Still, the systems of fish, amphibians, reptiles, and birds show various stages of the evolution of the circulatory system.

In fish, the system has only one circuit, with the blood being pumped through the capillaries of the gills and on to the capillaries of the body tissues. This is known as single circulation. The heart of fish is therefore only a single pump (consisting of two chambers). In amphibians and most reptiles, a double circulatory system is used, but the heart is not always completely separated into two pumps. Amphibians have a three-chambered heart.

Birds and mammals show complete separation of the heart into two pumps, for a total of four heart chambers; it is thought that the four-chambered heart of birds evolved independently from that of mammals.

Open circulatory system

The open circulatory system is an arrangement of internal transport present in animals such as molluscs and arthropods, in which fluid (called hemolymph) in a cavity called the hemocoel bathes the organs directly and there is no distinction between blood and interstitial fluid; this combined fluid is called hemolymph or haemolymph. Muscular movements by the animal during locomotion can facilitate hemolymph movement, but diverting flow from one area to another is limited. When the heart relaxes, blood is drawn back toward the heart through open-ended pores.
Hemolymph fills all of the interior hemocoel of the body and surrounds all cells. Hemolymph is composed of water, inorganic salts (mostly Na+, Cl-, K+, Mg2+, and Ca2+), and organic compounds (mostly carbohydrates, proteins, and lipids). The primary oxygen transporter molecule is hemocyanin.

There are free-floating cells, the hemocytes, within the hemolymph. They play a role in the arthropod immune system.

No circulatory system

Circulatory systems are absent in some animals, including flatworms (phylum Platyhelminthes). Their body cavity has no lining or enclosed fluid. Instead a muscular pharynx leads to an extensively branched digestive system that facilitates direct diffusion of nutrients to all cells. The flatworm's dorso-ventrally flattened body shape also restricts the distance of any cell from the digestive system or the exterior of the organism. Oxygen can diffuse from the surrounding water into the cells, and carbon dioxide can diffuse out. Consequently every cell is able to obtain nutrients, water and oxygen without the need of a transport system.

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